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Synthesis of Aryl(di)azinyl Ketones through Copper‐ and Iron‐catalyzed Oxidation of the Methylene Group of Aryl(di)azinylmethanes
Author(s) -
De Houwer Johan,
Abbaspour Tehrani Kourosch,
Maes Bert U. W.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108540
Sustainable Oxidations : An oxidation method to transform aryl(di)azinylmethanes into aryl(di)azinyl ketones is described. Base metals (copper and iron) as catalysts in combination with O 2 as the oxidant are used, which makes this method sustainable. The utility of this method is illustrated by the synthesis of 6‐(4‐methylbenzoyl)pyridine‐2‐carbaldehyde, which is an intermediate in the preparation of the drug Acrivastine.