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Overcoming the Instability of Gaseous Peptide Phosphate Ester Groups by Dimetal Protection
Author(s) -
Svane Simon,
Kryuchkov Fedor,
Lennartson Anders,
McKenzie Christine J.,
Kjeldsen Frank
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108481
Subject(s) - phosphate , chemistry , fragmentation (computing) , peptide , protecting group , phosphoproteomics , dissociation (chemistry) , phosphorylation , ion , combinatorial chemistry , biochemistry , organic chemistry , computer science , protein phosphorylation , alkyl , protein kinase a , operating system
Complex protection : Fragmentation of phosphorylated peptide ions by collision‐activated dissociation (CAD) is possible without facile detachment of the phosphate ester group when it is protected by a digallium complex (see scheme). The application of this dimetal phosphate ester stabilization (DIMPES) approach is believed to hold enormous potential for application in phosphoproteomics.