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Atom‐ and Step‐Economical Pathway to Chiral Benzobicyclo[2.2.2]octenones through Carbon–Carbon Bond Cleavage
Author(s) -
Liu Lantao,
Ishida Naoki,
Murakami Masahiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108446
Subject(s) - intramolecular force , alkene , cleavage (geology) , chemistry , carbon atom , asymmetric carbon , bond cleavage , stereochemistry , carbon fibers , computer science , combinatorial chemistry , catalysis , organic chemistry , algorithm , materials science , optically active , ring (chemistry) , fracture (geology) , composite number , composite material
In the nick of time : A nickel‐catalyzed asymmetric intramolecular alkene insertion reaction into cyclobutanones ( 1 ) has been developed. The reaction significantly reduces the number of steps required for the synthesis of chiral benzobicyclo[2.2.2]octenones ( 2 ).