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Palladium‐Catalyzed Intermolecular C(sp 3 )H Amidation
Author(s) -
Iglesias Álvaro,
Álvarez Rosana,
de Lera Ángel R.,
Muñiz Kilian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108351
Subject(s) - palladium , intermolecular force , imide , catalysis , chemistry , monomer , nitrogen , medicinal chemistry , polymer chemistry , organic chemistry , molecule , polymer
Dual capacity : A new palladium‐catalyzed intermolecular sequence consisting of the CH activation and amidation of methyl groups relies on N ‐fluorobis(phenylsulfonyl)imide (NFSI) as both the oxidant and the nitrogen source. The reaction provides the corresponding arylamines as bissulfonimides along with HF as the only by‐product. Both experimental and computational results suggest the involvement of a monomeric palladium(IV) intermediate.