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A General Approach to Optically Pure [5]‐, [6]‐, and [7]Heterohelicenes
Author(s) -
Žádný Jaroslav,
Jančařík Andrej,
Andronova Angelina,
Šámal Michal,
Vacek Chocholoušová Jana,
Vacek Jaroslav,
Pohl Radek,
Šaman David,
Císařová Ivana,
Stará Irena G.,
Starý Ivo
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108307
Subject(s) - helicene , cycloisomerization , computer science , information retrieval , content (measure theory) , mathematics , physics , chemistry , organic chemistry , molecule , quantum mechanics , catalysis , mathematical analysis
Spiral staircases : A general method for the preparation of optically pure [5]‐, [6]‐, and [7]heterohelicenes is based on a Co I ‐ or Ni 0 ‐catalyzed diastereoselective [2+2+2] cycloisomerization of centrally chiral triynes to deliver helicenes comprising two 2 H ‐pyran rings. The configuration, which can be predicted, does not depend on helicene length or functional groups present.