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An Asymmetric Hydroformylation Catalyst that Delivers Branched Aldehydes from Alkyl Alkenes
Author(s) -
Noonan Gary M.,
Fuentes José A.,
Cobley Christopher J.,
Clarke Matthew L.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108203
Subject(s) - hydroformylation , aldehyde , enantioselective synthesis , ligand (biochemistry) , chemistry , catalysis , organic chemistry , combinatorial chemistry , rhodium , biochemistry , receptor
Surprising selectivity : The first enantioselective hydroformylations of simple alkenes of type RCH 2 CHCH 2 to preferentially deliver the branched aldehyde product have been discovered using a new chiral ligand, named bobphos (see scheme). Established ligands are unselective in this reaction or show a slight preference towards the linear aldehyde.