Click‐Mediated Labeling of Bacterial Membranes through Metabolic Modification of the Lipopolysaccharide Inner Core | Zendy

Dumont Audrey | Zendy; Malleron Annie | Zendy; Awwad Monzer | Zendy; Dukan Sam | Zendy; Vauzeilles Boris | Zendy

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Click‐Mediated Labeling of Bacterial Membranes through Metabolic Modification of the Lipopolysaccharide Inner Core

Author(s) -

Dumont Audrey,

Malleron Annie,

Awwad Monzer,

Dukan Sam,

Vauzeilles Boris

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201108127

Subject(s) - bioorthogonal chemistry , click chemistry , membrane , bacteria , chemistry , biochemistry , core (optical fiber) , computer science , lipopolysaccharide , combinatorial chemistry , computational biology , biology , genetics , telecommunications , endocrinology

Clicking bugs : Metabolically active Gram‐negative bacteria can specifically incorporate an azide‐modified analogue of 3‐deoxy‐ D ‐manno‐octulosonic acid ( 1 ; see scheme) into the lipopolysaccharides on their membranes. This process adds a bioorthogonal chemical reporter onto the cell surface and allows the rapid fluorescent labeling of viable cells by click chemistry.

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