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Pyrrole Aminoimidazole Alkaloid Metabiosynthesis with Marine Sponges Agelas conifera and Stylissa caribica
Author(s) -
Stout E. Paige,
Wang YongGang,
Romo Daniel,
Molinski Tadeusz F.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108119
Subject(s) - chemistry , library science , humanities , art , computer science
Game‐SET‐match : Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell‐free enzyme preparations from PAI‐producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single‐electron transfers (SETs) that promote CC bond‐forming reactions of precursors.