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Reversible ON/OFF Nanoswitch for Organocatalysis: Mimicking the Locking and Unlocking Operation of CaMKII
Author(s) -
Schmittel Michael,
De Soumen,
Pramanik Susnata
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108089
Subject(s) - knoevenagel condensation , organocatalysis , chemistry , catalysis , nanotechnology , process (computing) , biochemical engineering , combinatorial chemistry , computer science , organic chemistry , materials science , enantioselective synthesis , engineering , operating system
Flip a switch : A nanoswitch uses chemical inputs to turn an organocatalytic Knoevenagel reaction on and off (see scheme: R=reactant, P=product). To stop catalysis the chemical input (pink and green) wraps around the inhibitory segment of the nanoswitch to effect release or unlocking of the switch. The process can run reversibly over three cycles without loss of activity.