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Unlocking the 1,2,3‐Triazole Ring Using Mechanical Force
Author(s) -
Lin Yuan,
Wang Qian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201108044
Subject(s) - azide , triazole , alkyne , ring (chemistry) , click chemistry , chemistry , 1,2,4 triazole , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
K(l)ick it into reverse: Mechanical force (ultrasound) may be employed to promote a retrocycloaddition reaction of a 1,2,3‐triazole to regenerate the parent azide and alkyne, a reaction that cannot be achieved by other means.