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Stimulated Release of Size‐Selected Cargos in Succession from Mesoporous Silica Nanoparticles
Author(s) -
Wang Cheng,
Li Zongxi,
Cao Dennis,
Zhao YanLi,
Gaines Justin W.,
Bozdemir O. Altan,
Ambrogio Michael W.,
Frasconi Marco,
Botros Youssry Y.,
Zink Jeffrey I.,
Stoddart J. Fraser
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107960
Subject(s) - mesoporous silica , ecological succession , nanoparticle , mesoporous material , nanotechnology , materials science , chemical engineering , chemistry , engineering , catalysis , biology , organic chemistry , ecology
Two birds with one stone : Covalent attachment of β‐cyclodextrin rings (yellow; see figure) to mesoporous silica nanoparticles (MSNs) results in a dual‐cargo release system into which differently sized cargos (blue and red spheres) can be loaded and then released in sequence when triggered by two different stimuli. The smaller molecules are released by lowering the pH value and the larger ones released after cleavage of the cyclodextrins from the MSN surface.