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Back Cover: Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)‐Functionalized, Self‐Assembled Nanoconjugate (Angew. Chem. Int. Ed. 2/2012)
Author(s) -
Liu Gang,
Choi Ki Young,
Bhirde Ashwinkumar,
Swierczewska Magdalena,
Yin Juan,
Lee Sang Wook,
Park Jae Hyung,
Hong Jong In,
Xie Jin,
Niu Gang,
Kiesewetter Dale O.,
Lee Seulki,
Chen Xiaoyuan
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107924
Subject(s) - chemistry , nanoparticle , penetration (warfare) , combinatorial chemistry , zinc , hyaluronic acid , nanotechnology , small molecule , biophysics , biochemistry , organic chemistry , materials science , engineering , biology , operations research , genetics
A new platform for delivering siRNA is described by S. Lee, X. Chen, et al. in their Communication on page 445 ff. Multifunctional, self‐assembled, polymeric nanoparticles composed of biodegradable hyaluronic acid, for selectively targeting tumors and cell penetration, and a phosphate‐binding Zn II dipicolylamine analogue, for high siRNA binding affinity, provide simultaneous delivery of small‐molecule drugs along with siRNA. This system offers additive and synergistic therapeutic effects.