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A New Direction in CH Alkenylation: Silanol as a Helping Hand
Author(s) -
Mewald Marius,
Schiffner Julia A.,
Oestreich Martin
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107859
Subject(s) - silanol , regioselectivity , toluene , chemistry , palladium , phenols , catalysis , oxidative phosphorylation , combinatorial chemistry , organic chemistry , biochemistry
Director's cut: Not only conventional alcohols but also silanols can act as directing groups in oxidative palladium( II )‐catalyzed CH alkenylations. The silicon‐tethered hydroxy groups are “traceless”, thereby facilitating the regioselective CH activation of toluene derivitives as well as phenols (see scheme).