A Catalytic Multicomponent Approach for the Stereoselective Synthesis of  cis ‐4,5‐Disubstituted Pyrrolidinones and Tetrahydro‐3 H ‐pyrrolo[3,2‐ c ]quinolines | Zendy

Roy Sudipta | Zendy; Reiser Oliver | Zendy

Premium

A Catalytic Multicomponent Approach for the Stereoselective Synthesis of cis ‐4,5‐Disubstituted Pyrrolidinones and Tetrahydro‐3 H ‐pyrrolo[3,2‐ c ]quinolines

Author(s) -

Roy Sudipta,

Reiser Oliver

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201107831

Subject(s) - pyrrole , pyrrolidinones , stereoselectivity , set (abstract data type) , stereochemistry , combinatorial chemistry , chemistry , catalysis , computer science , organic chemistry , programming language

Ménage à trois : In a three‐component reaction, furancarbaldehydes 1 , anilines 2 , and the monocyclopropanated pyrrole 3 can be assembled highly stereoselectively to give cis ‐4,5‐disubstituted pyrrolidinones (see scheme; Boc= tert ‐butoxycarbonyl). The products are lead structures for pharmaceutically important compounds.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research