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A Catalytic Multicomponent Approach for the Stereoselective Synthesis of cis ‐4,5‐Disubstituted Pyrrolidinones and Tetrahydro‐3 H ‐pyrrolo[3,2‐ c ]quinolines
Author(s) -
Roy Sudipta,
Reiser Oliver
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107831
Subject(s) - pyrrole , pyrrolidinones , stereoselectivity , set (abstract data type) , stereochemistry , combinatorial chemistry , chemistry , catalysis , computer science , organic chemistry , programming language
Ménage à trois : In a three‐component reaction, furancarbaldehydes 1 , anilines 2 , and the monocyclopropanated pyrrole 3 can be assembled highly stereoselectively to give cis ‐4,5‐disubstituted pyrrolidinones (see scheme; Boc= tert ‐butoxycarbonyl). The products are lead structures for pharmaceutically important compounds.