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Ruthenium NHC Catalyzed Highly Asymmetric Hydrogenation of Benzofurans
Author(s) -
Ortega Nuria,
Urban Slawomir,
Beiring Bernhard,
Glorius Frank
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107811
Subject(s) - ruthenium , regioselectivity , carbene , catalysis , asymmetric hydrogenation , chemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis
H 2 ‐O‐T ! Aromatic O ‐heterocycles are a challenging substrates for asymmetric hydrogenation ( H 2 ). An in situ formed chiral N‐heterocyclic carbene (NHC) ruthenium complex allows the high yielding, completely regioselective, and highly asymmetric hydrogenation of substituted benzofurans at room T emperature, giving valuable 2,3‐dihydrobenzofurans (see scheme).