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An O‐Centered Structure of the Trinuclear Copper Center in the Cys500Ser/Glu506Gln Mutant of CueO and Structural Changes in Low to High X‐Ray Dose Conditions
Author(s) -
Komori Hirofumi,
Sugiyama Ryosuke,
Kataoka Kunishige,
Higuchi Yoshiki,
Sakurai Takeshi
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107739
Subject(s) - copper , multicopper oxidase , crystallography , x ray , chemistry , spectral line , x ray crystallography , materials science , diffraction , physics , optics , enzyme , biochemistry , organic chemistry , astronomy , laccase
Right on CueO: The O‐centered structure of the trinuclear copper center in a multicopper oxidase (CueO) was shown to be an intermediate of the four‐electron reduction of dioxygen (see picture). This structure was determined by in situ data collection of X‐ray diffractions and copper K‐edge spectra at low to high X‐ray dose conditions.