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First Solution Structures of Seven‐Transmembrane Helical Proteins
Author(s) -
Zerbe Oliver
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107639
Subject(s) - transmembrane protein , relaxation (psychology) , residual dipolar coupling , chemistry , paramagnetism , transmembrane domain , nuclear magnetic resonance , nuclear overhauser effect , biophysics , crystallography , nuclear magnetic resonance spectroscopy , physics , biology , biochemistry , membrane , condensed matter physics , neuroscience , receptor
A mastered challenge : The recent solution structures of seven‐transmembrane proteins, in particular of proteorhodopsin, have been reported. The structures are a major advance in structural biology and were determined based on experimental restrains derived from nuclear Overhauser effects (NOEs), paramagnetic relaxation enhancements (PREs), and residual dipolar couplings (RDCs, see picture).