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Is Enantiomer Assignment Possible by NMR Spectroscopy Using Residual Dipolar Couplings from Chiral Nonracemic Alignment Media?—A Critical Assessment
Author(s) -
Berger Robert,
Courtieu Jacques,
Gil Roberto R.,
Griesinger Christian,
Köck Matthias,
Lesot Philippe,
Luy Burkhard,
Merlet Denis,
NavarroVázquez Armando,
Reggelin Michael,
Reinscheid Uwe M.,
Thiele Christina M.,
Zweckstetter Markus
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107626
Subject(s) - residual dipolar coupling , absolute configuration , residual , enantiomer , dipole , anisotropy , chemistry , observable , nuclear magnetic resonance spectroscopy , computational chemistry , nuclear magnetic resonance , physics , stereochemistry , organic chemistry , computer science , optics , algorithm , quantum mechanics
Insensitive towards inversion : Can residual dipolar couplings (RDCs) and other anisotropic NMR observables be used to determine absolute configuration? A critical assessment of recent approaches is provided to determine the absolute configuration from RDCs.