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A Highly Efficient Gold‐Catalyzed Oxidative CC Coupling from CH Bonds Using Air as Oxidant
Author(s) -
Xie Jin,
Li Huamin,
Zhou Jiecong,
Cheng Yixiang,
Zhu Chengjian
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107605
Subject(s) - catalysis , coupling (piping) , oxidative coupling of methane , oxidative phosphorylation , process (computing) , combinatorial chemistry , chemistry , reaction conditions , protocol (science) , computer science , coupling reaction , organic chemistry , materials science , biochemistry , metallurgy , medicine , alternative medicine , pathology , operating system
A breath of fresh air : The title reaction has been developed for the coupling of amines with nitroalkanes and different unmodified ketones using air as the sole oxidant under mild reaction conditions. The safe, convenient, and environmentally benign process, as well as the low catalyst loading, short reaction time, and good yields make this protocol very practical (see scheme).