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Direct Titanium‐Mediated Conversion of Ketones into Enamides with Ammonia and Acetic Anhydride
Author(s) -
Reeves Jonathan T.,
Tan Zhulin,
Han Zhengxu S.,
Li Guisheng,
Zhang Yongda,
Xu Yibo,
Reeves Diana C.,
Gonnella Nina C.,
Ma Shengli,
Lee Heewon,
Lu Bruce Z.,
Senanayake Chris H.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107601
Subject(s) - acetic anhydride , reagent , ethylenediamine , ammonia , combinatorial chemistry , chemistry , titanium , organic chemistry , computer science , catalysis
A one‐step conversion of ketones into N ‐acetyl enamides was developed. The process employs safe and inexpensive reagents, proceeds under mild conditions, and tolerates diverse functional groups. The addition of edte ( N , N , N ′, N ′‐tetrakis(2‐hydroxyethyl)ethylenediamine) prior to workup enables water solubilization of Ti alkoxides and allows a simple extractive workup.