Exploiting the Electrophilic Properties of Indole Intermediates: New Options in Designing Asymmetric Reactions | Zendy

Loh Charles C. J. | Zendy; Enders Dieter | Zendy

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Exploiting the Electrophilic Properties of Indole Intermediates: New Options in Designing Asymmetric Reactions

Author(s) -

Loh Charles C. J.,

Enders Dieter

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201107575

Subject(s) - umpolung , iminium , indole test , electrophile , chemistry , reactivity (psychology) , organocatalysis , combinatorial chemistry , nucleophile , catalysis , computational chemistry , enantioselective synthesis , stereochemistry , organic chemistry , medicine , alternative medicine , pathology

Think electrophilic : While the classical π‐excessive indole is well‐known for its electrophilic substitutions at position C3, recent advances in asymmetric catalysis resulted in a surge in utilizing the less discussed electrophilic properties of iminium‐type intermediates (see picture) in complex annulations of indoles. Advances in Au I catalysis also allow an umpolung of the classical indole C3 reactivity.

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