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Cover Picture: Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis (Angew. Chem. Int. Ed. 6/2012)
Author(s) -
Quitterer Felix,
List Anja,
Eisenreich Wolfgang,
Bacher Adelbert,
Groll Michael
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107547
Subject(s) - biosynthesis , archaea , chemistry , stereochemistry , dna ligase , ionic liquid , amino acid , active site , crystal structure , crystallography , catalysis , enzyme , biochemistry , gene
The unusual amino acid pyrrolysine is found in the active site of the methylamine methyltransferases of certain methanogenic archaea. Methylornithine, an intermediate in pyrrolysine biosynthesis, is formed by the PylB‐catalyzed isomerization of lysine. In their Communication on page 1339 ff., M. Groll and co‐workers present the crystal structure of PylB in complex with its reaction product and suggest a fragmentation–recombination mechanism via a glycyl radical intermediate.