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Nonlinear Enhancement of Chiroptical Response through Subcomponent Substitution in M 4 L 6 Cages
Author(s) -
Ousaka Naoki,
Clegg Jack K.,
Nitschke Jonathan R.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107532
Subject(s) - diastereomer , enantiopure drug , substitution (logic) , twist , metal , nonlinear system , stereochemistry , chemistry , computer science , crystallography , mathematics , combinatorics , physics , enantioselective synthesis , organic chemistry , quantum mechanics , geometry , programming language , catalysis
One for all, all for one : A self‐assembled M 4 L 6 cage, incorporating small amounts of enantiopure subcomponents at the peripheries, forms predominantly with a one‐handed twist at all metal centers. Strong stereochemical coupling between metal centers in the cage amplifies energy differences between the ΔΔΔΔ and ΛΛΛΛ diastereomers as compared to analogous mononuclear metal complexes (see picture; red and gray bars denote chiral and achiral subcomponents, respectively).