Highly Efficient Narasaka–Heck Cyclizations Mediated by P(3,5‐(CF 3 ) 2 C 6 H 3 ) 3 : Facile Access to N‐Heterobicyclic Scaffolds | Zendy

Faulkner Adele | Zendy; Bower John F. | Zendy

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Highly Efficient Narasaka–Heck Cyclizations Mediated by P(3,5‐(CF 3 ) 2 C 6 H 3 ) 3 : Facile Access to N‐Heterobicyclic Scaffolds

Author(s) -

Faulkner Adele,

Bower John F.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201107511

Subject(s) - steric effects , oxime , key (lock) , palladium , chemistry , computer science , process (computing) , range (aeronautics) , catalysis , combinatorics , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , mathematics , materials science , operating system , composite material

N‐heterobicyclic scaffolds : Highly efficient palladium‐catalyzed cyclizations of oxime esters with cyclic alkenes were used as a general entry to perhydroindole and related scaffolds. The chemistry is reliant upon the use of P(3,5‐(CF 3 ) 2 C 6 H 3 ) 3 for the key C(sp 3 )N bond‐forming process and this facilitates cyclizations with enhanced levels of efficiency across a range of sterically and electronically distinct substrates.

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