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Distinguishing DNA by Analog‐to‐Digital‐like Conversion by Using Optofluidic Lasers
Author(s) -
Sun Yuze,
Fan Xudong
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107381
Subject(s) - laser , optoelectronics , materials science , optics , dna , physics , chemistry , biochemistry
Laser precision : A highly sensitive technique based on laser emission for differentiating a target DNA strand from strands that contain single base mismatches has been developed. Laser emission is used to amplify the small difference in signals that are generated by the different strands after hybridization with a molecular beacon (MB, see picture) in a conversion that is similar to analog‐to‐digital.