On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition‐Metal Complexes | Zendy

Simmons Eric M. | Zendy; Hartwig John F. | Zendy

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On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition‐Metal Complexes

Author(s) -

Simmons Eric M.,

Hartwig John F.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201107334

Subject(s) - kinetic isotope effect , deuterium , chemistry , kinetic energy , isotope , interpretation (philosophy) , bond cleavage , computational chemistry , thermodynamics , organic chemistry , catalysis , atomic physics , nuclear physics , physics , computer science , quantum mechanics , programming language

Rate versus selectivity determining : The measurement of a kinetic isotope effect (KIE) can provide valuable information about the mechanism of a reaction, but care must be taken in the design and interpretation of KIE experiments. Depending on the experiment that is conducted, the observation of a primary KIE resulting from H/D substitution does not necessarily imply that CH bond cleavage occurs during the rate‐determining step of a reaction. FG=functional group.

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