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[(Cp‐R)M(CO) 3 ] (M=Re or 99m Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX
Author(s) -
Can Daniel,
Spingler Bernhard,
Schmutz Paul,
Mendes Filipa,
Raposinho Paula,
Fernandes Célia,
Carta Fabrizio,
Innocenti Alessio,
Santos Isabel,
Supuran Claudiu T.,
Alberto Roger
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107333
Subject(s) - carbonic anhydrase , chemistry , carbonic anhydrase ii , conjugate , molecule , cyclopentadienyl complex , enzyme , in vitro , carbonic anhydrase inhibitor , stereochemistry , radiochemistry , biochemistry , organic chemistry , mathematical analysis , mathematics , catalysis
Enhanced receptor selectivity : Carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non‐radioactive Re compounds with their radioactive 99m Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp‐R)M(CO) 3 ] (Cp=cyclopentadienyl, M=Re, 99m Tc) with R being a highly potent carbonic‐anhydrase‐targeting vector is reported (see picture).