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Quantitative Replacement of Cetyl Trimethylammonium Bromide by Cationic Thiol Ligands on the Surface of Gold Nanorods and Their Extremely Large Uptake by Cancer Cells
Author(s) -
Vigderman Leonid,
Manna Pramit,
Zubarev Eugene R.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107304
Subject(s) - nanorod , cationic polymerization , bromide , monolayer , cytotoxicity , thiol , chemistry , biocompatible material , cancer cell , nuclear chemistry , chemical engineering , materials science , nanotechnology , in vitro , combinatorial chemistry , polymer chemistry , inorganic chemistry , cancer , organic chemistry , biochemistry , biomedical engineering , medicine , engineering
Stable and biocompatible : The chemical composition of synthesized cationic thiolate‐monolayer‐protected gold nanorods was precisely determined. In vitro cell culture experiments showed no cytotoxicity of these nanorods, and the number of nanorods that were taken up by each cancer cell exceeded two million particles (see picture).