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Palladium‐Catalyzed Dehydrative Heck Olefination of Secondary Aryl Alcohols in Ionic Liquids: Towards a Waste‐Free Strategy for Tandem Synthesis of Stilbenoids
Author(s) -
Kumar Rakesh,
Shard Amit,
Bharti Richa,
Thopate Yogesh,
Sinha Arun Kumar
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107261
Subject(s) - aryl , ionic liquid , tandem , chemistry , palladium , halide , organic chemistry , catalysis , sequence (biology) , microwave irradiation , heck reaction , combinatorial chemistry , materials science , alkyl , composite material , biochemistry
All in one : A tandem strategy has been developed wherein secondary aryl alcohols are directly coupled with aryl halides to provide stilbenoids through a dehydrative Heck sequence in the ionic liquid [hmim]Br, and with water as a by‐product under microwave irradiation (see scheme). Classical methods do not permit this sequence to proceed in one pot, and some methods require multiple steps. hmim=1‐ n ‐hexyl‐3‐methylimidazolium.