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An Activity‐Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363
Author(s) -
Chang Jae Won,
Moellering Raymond E.,
Cravatt Benjamin F.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107236
Subject(s) - hydrolase , profiling (computer programming) , enzyme , membrane , subcellular localization , computer science , information retrieval , chemistry , computational biology , biochemistry , biology , gene , programming language
Profiling enzyme activities : A selective, activity‐based imaging probe is described for the integral membrane hydrolase KIAA1363 and used to determine the subcellular localization and half‐life of this enzyme in human cancer cells (see picture).