Synthesis of a Biologically Active Triazole‐Containing Analogue of Cystatin A Through Successive Peptidomimetic Alkyne–Azide Ligations | Zendy

Valverde Ibai E. | Zendy; Lecaille Fabien | Zendy; Lalmanach Gilles | Zendy; Aucagne Vincent | Zendy; Delmas Agnès F. | Zendy

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Synthesis of a Biologically Active Triazole‐Containing Analogue of Cystatin A Through Successive Peptidomimetic Alkyne–Azide Ligations

Author(s) -

Valverde Ibai E.,

Lecaille Fabien,

Lalmanach Gilles,

Aucagne Vincent,

Delmas Agnès F.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201107222

Subject(s) - peptidomimetic , click chemistry , cycloaddition , azide , combinatorial chemistry , triazole , alkyne , chemistry , peptide , stereochemistry , organic chemistry , catalysis , biochemistry

“Click” protein : Cu I ‐catalyzed cycloaddition of azides and terminal alkynes has been applied to the successive ligations of three unprotected peptide fragments. Peptidomimetic triazole ligation (PTL, see scheme) as a new method for the chemical production of bioactive proteins is applied for the synthesis of a triazole‐containing analogue of the 97 amino acid protein cystatin A.

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