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A Nanoscale Force Probe for Gauging Intermolecular Interactions
Author(s) -
Kim Minkyu,
Wang ChienChung,
Benedetti Fabrizio,
Marszalek Piotr E.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107210
Subject(s) - intermolecular force , fingerprint (computing) , force spectroscopy , nanoscopic scale , nanotechnology , molecule , atomic force microscopy , sensitivity (control systems) , ligand (biochemistry) , computer science , chemistry , materials science , chemical physics , receptor , artificial intelligence , engineering , biochemistry , organic chemistry , electronic engineering
Into low force regime : A universal molecular force probe for measuring by AFM the strength of receptor–ligand and protein–protein complexes was developed. The protein‐based force probe has the sensitivity on the order of piconewtons and provides a single‐molecule fingerprint for identifying mechanical rupture events of individual complexes (see picture).