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Reagent‐Installed Capsule Network: Selective Thiocarbamoylation of Aromatic Amines in Crystals with Preinstalled CH 3 NCS
Author(s) -
Inokuma Yasuhide,
Ning GuoHong,
Fujita Makoto
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107190
Subject(s) - reagent , selectivity , chemistry , leaching (pedology) , molecule , organic solvent , solvent , combinatorial chemistry , inorganic chemistry , organic chemistry , chemical engineering , catalysis , environmental science , soil science , soil water , engineering
Crystalline reagent capsules were prepared by installing CH 3 NCS into networked molecular capsules. While the tight encapsulation completely prevented leaching of reagent molecules into the supernatant, introduction of amines into the interstitial pores triggered reagent delivery. As a result, enhanced substrate selectivity was observed in crystalline‐state thiocarbamoylation (see picture; 86:14 in favor of 2‐ vs. 1‐naphthylamine).