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Well‐Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis ‐Diols
Author(s) -
Li Yuanpei,
Xiao Wenwu,
Xiao Kai,
Berti Lorenzo,
Luo Juntao,
Tseng Harry P.,
Fung Gabriel,
Lam Kit S.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107144
Subject(s) - nanocarriers , chemistry , in vivo , mannitol , drug , micelle , drug delivery , combinatorial chemistry , cleavage (geology) , food and drug administration , in vitro , computer science , pharmacology , organic chemistry , biochemistry , aqueous solution , medicine , materials science , biology , microbiology and biotechnology , composite material , fracture (geology)
Demand and deliver : Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol.