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Deep‐Tissue Photoacoustic Tomography of a Genetically Encoded Near‐Infrared Fluorescent Probe
Author(s) -
Filonov Grigory S.,
Krumholz Arie,
Xia Jun,
Yao Junjie,
Wang Lihong V.,
Verkhusha Vladislav V.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201107026
Subject(s) - photoacoustic imaging in biomedicine , fluorescence , photoacoustic tomography , fluorescent protein , tomography , infrared , materials science , optics , green fluorescent protein , biology , gene , physics , genetics
Skin‐deep : The combination of a near‐infrared fluorescent protein (iRFP) and deep‐tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4 mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.