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One‐Pot Arylative Epoxidation of Ketones by Employing Amphoteric Bromoperfluoroarenes
Author(s) -
Li Zhou,
Gevorgyan Vladimir
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106969
Subject(s) - cascade , computer science , chemistry , combinatorial chemistry , organic chemistry , chromatography
A one‐pot cascade synthesis of perfluoroaryl oxiranes 2 by the arylative epoxidation of enolizable ketones 1 with bromopentafluorobenzene (PFPBr) and derivatives ( 3 ) is reported. PFPBr is utilized as an equivalent of Br + and PFP − in this highly efficient, easily scaled‐up, diastereoselective epoxidation reaction, which produces synthetically useful polyfluoroaryl oxiranes.
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