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Photocontrol of the Translocation of Molecules, Peptides, and Quantum Dots through Cell and Lipid Membranes Doped with Azobenzene Copolymers
Author(s) -
Sebai Sarra C.,
Milioni Dimitra,
Walrant Astrid,
Alves Isabel D.,
Sagan Sandrine,
Huin Cécile,
Auvray Loic,
Massotte Dominique,
Cribier Sophie,
Tribet Christophe
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106777
Subject(s) - azobenzene , isomerization , copolymer , photochromism , chemistry , membrane , polymer , molecule , photochemistry , organic chemistry , biochemistry , catalysis
Light opens : Photocontrolled transmembrane passage of soluble dyes and delivery of small peptides into mammalian cells has been achieved using azobenzene‐modified polymers (AMPs) as permeabilizing agents. Irradiation with UV and visible light triggers polarity switches upon cis – trans isomerization of the azobenzene moieties. Photoresponsive permeability and pore opening promoted by trans ‐AMPs, but not cis ‐AMPs, in supported lipid bilayers are observed.