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Total Synthesis of Carolacton, a Highly Potent Biofilm Inhibitor
Author(s) -
Schmidt Thomas,
Kirschning Andreas
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106762
Subject(s) - negishi coupling , biofilm , aldol reaction , chemistry , total synthesis , stereochemistry , combinatorial chemistry , coupling reaction , bacteria , organic chemistry , biology , catalysis , genetics
Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal‐mediated key transformations such as the Ley and the Duthaler–Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki–Hiyama–Kishi and Negishi–Fu CC coupling reactions.