Palladium‐Catalyzed 2,2,2‐Trifluoroethylation of Organoboronic Acids and Esters | Zendy

Zhao Yanchuan | Zendy; Hu Jinbo | Zendy

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Palladium‐Catalyzed 2,2,2‐Trifluoroethylation of Organoboronic Acids and Esters

Author(s) -

Zhao Yanchuan,

Hu Jinbo

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201106742

Subject(s) - reagent , aryl , palladium , combinatorial chemistry , catalysis , chemistry , boronic acid , variety (cybernetics) , scheme (mathematics) , computer science , organic chemistry , mathematics , artificial intelligence , mathematical analysis , alkyl

Trifluoroethylation : Aryl boronic acids can be catalytically trifluoroethylated with the readily available reagent CF 3 CH 2 I (see scheme, dba=dibenzylideneacetone). The reaction tolerates a variety of functional groups and can be extended to the trifluoroethylation of aryl or alkenyl boronic esters. The method is also suitable for the late‐stage installation of the CF 3 CH 2 group into target molecules.

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