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1,2‐Dicarbonyl Compounds as Pronucleophiles in Organocatalytic Asymmetric Transformations
Author(s) -
Raimondi Wilfried,
Bonne Damien,
Rodriguez Jean
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106741
Subject(s) - organocatalysis , domino , enantioselective synthesis , chemistry , catalysis , reactive intermediate , combinatorial chemistry , organic chemistry
Organocatalysis likes them too! 1,2‐dicarbonyl compounds possess high synthetic potential because of their adjacent multiple reactive centers. Recent contributions indicate that these reactive species, with an appropriate activation mode, may also act as efficient pronucleophiles in asymmetric organocatalyzed sequential or domino transformations including CC or CN bond formation (see scheme).