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Copper(I) Enolate Complexes in α‐Arylation Reactions: Synthesis, Reactivity, and Mechanism
Author(s) -
Huang Zheng,
Hartwig John F.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106719
Subject(s) - reactivity (psychology) , copper , chemistry , aryl , combinatorial chemistry , mechanism (biology) , medicinal chemistry , organic chemistry , computational chemistry , epistemology , philosophy , medicine , alkyl , alternative medicine , pathology
Copper is all bound up : The copper‐catalyzed α‐arylation of carbonyl compounds occurs through oxidative addition of iodoarenes to the C‐bound Cu I enolate species 1 to form an aryl–Cu III intermediate (see scheme). Computational results provide insight into the origins of the relative reactivity of various Cu I enolate complexes in the reactions with iodoarenes.