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Highly Selective Trifluoromethylation of 1,3‐Disubstituted Arenes through Iridium‐Catalyzed Arene Borylation
Author(s) -
Liu Tianfei,
Shao Xinxin,
Wu Yaming,
Shen Qilong
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106673
Subject(s) - borylation , trifluoromethylation , iridium , combinatorial chemistry , chemistry , pinacol , catalysis , organic chemistry , trifluoromethyl , alkyl , aryl
The old one two : A sequential iridium‐catalyzed borylation and copper‐catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. The advantages of this tandem procedure are demonstrated by the late‐stage trifluoromethylation of a number of biologically active molecules.