Highly Selective Trifluoromethylation of 1,3‐Disubstituted Arenes through Iridium‐Catalyzed Arene Borylation | Zendy

Liu Tianfei | Zendy; Shao Xinxin | Zendy; Wu Yaming | Zendy; Shen Qilong | Zendy

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Highly Selective Trifluoromethylation of 1,3‐Disubstituted Arenes through Iridium‐Catalyzed Arene Borylation

Author(s) -

Liu Tianfei,

Shao Xinxin,

Wu Yaming,

Shen Qilong

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201106673

Subject(s) - borylation , trifluoromethylation , iridium , combinatorial chemistry , chemistry , pinacol , catalysis , organic chemistry , trifluoromethyl , alkyl , aryl

The old one two : A sequential iridium‐catalyzed borylation and copper‐catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. The advantages of this tandem procedure are demonstrated by the late‐stage trifluoromethylation of a number of biologically active molecules.

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