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Selenenylsulfide‐Linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human “Hepatic Se Metabolite A”
Author(s) -
Boutureira Omar,
Bernardes Gonçalo J. L.,
FernándezGonzález Marta,
Anthony Daniel C.,
Davis Benjamin G.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106658
Subject(s) - glycopeptide , metabolite , glycoprotein , selenium , computer science , homogeneous , chemistry , glycan , computational biology , biochemistry , glycoconjugate , information retrieval , combinatorial chemistry , biology , organic chemistry , mathematics , antibiotics , combinatorics
Introducing selenium : The synthesis and full characterization of human hepatic Se metabolite A has been accomplished by using a robust, efficient, and Cys‐specific selenenylation protocol (see scheme; NaPi=sodium phosphate). The selenenylsulfide linkage is sufficiently stable to allow quantification of Se‐containing glycoconjugates in biological fluids by using atomic detection methods.