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Plug and Play with RNA
Author(s) -
Mayer Günter,
Lennarz Sabine,
Rohrbach Falk,
Tolle Fabian
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106636
Subject(s) - aptamer , rna , riboswitch , ribozyme , chemistry , computational biology , small molecule , microbiology and biotechnology , nanotechnology , biochemistry , biology , non coding rna , gene , materials science
Retooling RNA : RNA aptamers are high‐affinity ligands that can be assembled with other structures to yield multivalent molecules. These properties have been addressed in two recent studies: One describes a GFP‐like RNA reporter used to study the dynamics of endogenous RNA; the other study reports on an aptamer‐templated assembly of multi‐enzyme complexes in bacteria for the controlled production of secondary molecules (see picture).