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A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides
Author(s) -
Wilson Rebecca M.,
Stockdill Jennifer L.,
Wu Xiangyang,
Li Xuechen,
Vadola Paul A.,
Park Peter K.,
Wang Ping,
Danishefsky Samuel J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106628
Subject(s) - peptide bond , chemistry , amide , combinatorial chemistry , peptide , organic chemistry , biochemistry
We describe herein our recent explorations in the field of isonitrile chemistry. An array of broadly useful coupling methodologies has been developed for the formation of peptidyl and glycopeptidyl amide bonds. We further describe the application of these methods to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles.