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Palladium‐Catalyzed Decarboxylative CH Bond Arylation of Thiophenes
Author(s) -
Hu Peng,
Zhang Min,
Jie Xiaoming,
Su Weiping
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106451
Subject(s) - catalysis , thiophene , reagent , palladium , chemistry , stoichiometry , medicinal chemistry , decarboxylation , combinatorial chemistry , organic chemistry
An efficient method involving a Pd/PCy 3 catalyst in combination with a stoichiometric amount of Ag 2 CO 3 has been established for the decarboxylative CH bond arylation of thiophenes to give 2‐arylthiophenes (see scheme; Cy=cyclohexyl). Electron‐rich, electron‐deficient, and heterocyclic benzoic acids can be used as the arylating reagent and a broad range of substituents on the thiophene are tolerated.