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Isolation and Total Synthesis of Icumazoles and Noricumazoles—Antifungal Antibiotics and Cation‐Channel Blockers from Sorangium cellulosum
Author(s) -
Barbier Jenny,
Jansen Rolf,
Irschik Herbert,
Benson Stefan,
Gerth Klaus,
Böhlendorf Bettina,
Höfle Gerhard,
Reichenbach Hans,
Wegner Jens,
Zeilinger Carsten,
Kirschning Andreas,
Müller Rolf
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106435
Subject(s) - antifungal , derivatization , total synthesis , chemistry , stereochemistry , combinatorial chemistry , mass spectrometry , biology , chromatography , microbiology and biotechnology
Joint efforts: The antifungal icumazole A, the potassium‐ion‐channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.