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Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells
Author(s) -
Wirth Tanja,
Schmuck Kianga,
Tietze Lutz F.,
Sieber Stephan A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106334
Subject(s) - aldehyde dehydrogenase , aldehyde , lung cancer , computer science , computational biology , information retrieval , enzyme , cancer research , chemistry , biochemistry , biology , medicine , oncology , catalysis
Reacquiring the target : A proteomic profiling approach has been used to show that aldehyde dehydrogenase 1 may be an additional or alternative target of duocarmycin. Selective inhibition of this enzyme in lung cancer cells explains the antitumor activity of duocarmycin analogues (see scheme).