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ImmunoPods: Polymer Shells with Native Antibody Cross‐Links
Author(s) -
Zhang Ke,
Zheng Dan,
Hao Liangliang,
Cutler Joshua I.,
Auyeung Evelyn,
Mirkin Chad A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106313
Subject(s) - propargyl , polymer , chemistry , colloidal gold , ether , dissolution , nanoparticle , combinatorial chemistry , bioconjugation , conjugate , polymer chemistry , nanotechnology , chemical engineering , catalysis , materials science , organic chemistry , mathematical analysis , mathematics , engineering
Nanopods functionalized with anti‐HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross‐linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod–protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.