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The Direct Asymmetric α Alkylation of Ketones by Brønsted Acid Catalysis
Author(s) -
Song Liu,
Guo QiXiang,
Li XingCheng,
Tian Juan,
Peng YunGui
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201106275
Subject(s) - alkylation , phosphoric acid , brønsted–lowry acid–base theory , catalysis , chemistry , organic chemistry , computer science , combinatorial chemistry
Being direct : A Brønsted acid catalyzed α alkylation of ketones is described. The phosphoric acid 1 promotes this reaction to afford the desired products with high yields, high diastereoselectivities, and good to excellent enantioselectivites.
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